Conduct mechanistic or semi-mechanistic PKPD modeling to build the correlation between PK and PD/efficacy

Predict maximum absorbable dose (MAD), human PK, and DDI with PBPK modeling

Explore drug ADME mechanistically with PBPK modeling

Apply PKPD modeling and PBPK modeling into human efficacious dose prediction

Collaborate with clinical pharmacology to provide a rationale for dose escalation and dose range in phase 1 studies

Evaluate novel in silico tools and methodology to improve human PK and dose prediction

Provide DMPK and PK/PD expertise and input into related documents such as Investigator Brochures, SOPs, study reports, manuscripts, summaries for regulatory authorities, INDs, NDAs and sNDAs

Other duties as assigned

A Ph.D. degree in pharmacokinetics, pharmacology, or pharmaceutical Sciences with hands-on experience on PKPD modeling is required