About BeiGene and BeiGene Institute

Over the past decade BeiGene has grown exponentially and become an industry leader with a robust drug pipeline combined with strong production capacity. In addition, as an emerging industry leader with over 7000 employees globally, BeiGene has built a world-class clinical development team and a leading commercial team to bring accessible and affordable medicines to patients around the world.

As part of its ongoing efforts to drive the development of truly innovative and transformative medicines, BeiGene is creating a brand-new research institution in Shanghai, China, BeiGene Institute. Our goal is to establish a cross-disciplinary research organization where cutting-edge science and technology drive the discovery of impactful Insights into human health and disease. BeiGene Institute functions as an independent research entity within BeiGene to enable sustainable scientific discoveries and innovation.

Why BeiGene Institute

 BeiGene Institute is a diverse and inclusive community where scientists will bring their expertise, creativity, and originality to a group of dynamic colleagues and collaborators.

 BeiGene Institute is structured with groups with specific research focuses. Individual group head leads a team staffed with postdocs and research associates. You will have a unique opportunity for career development in an environment that crosses between industry and academia.

 Scientists will have access to state-of-the-art technologies to perform ground-breaking work to address fundamental biology and technology questions. We are well-supported to carry out independent research and pursue collaborations within and beyond BeiGene.

 Besides being encouraged to publish their research work, we are empowered to explore the translational potential of our own scientific discoveries and play an active role in our collective effort of discovering drug candidates and establishing biomarkers across major diseases, including cancer and inflammatory diseases.

 We offer a highly competitive compensation package, and rank and salary commensurate with qualifications.

We are seeking independent and creative Research Investigators to join Dr. Gu’s group.

Dr. Wei Gu recently joined BeiGene as the research chief of BeiGene Institute. The main research focuses of Dr. Gu’s group are:

 -gastric-intestinal cancer development and new therapeutic target discovery

 -gut hormone discovery

 -gut stem cell biology and cell therapy potentials.

Job responsibilities：

The successful candidates will：

 -Initiate and conduct independent research

 -Collaborate with other group members to drive innovation and productivity

 -Mentor and support junior staff members

Requirements:

 -The success applicants will have a Ph.D. in 2022 or earlier.

 -The applicants should have a solid background and significant experience in one or more of the following areas:

 stem cell biology, cancer biology, multi-omics integration, and metabolism biology

 -A solid record of scientific accomplishment

 -Ability to independently design and execute experiments, interpret data, and identify appropriate follow-up strategies

 -Ability to collaborate in a dynamic environment

 -Ability to write and publish manuscripts

-Specialized skills: (key skills are highlighted)

Molecular Biology: Molecular Cloning and Vector Designation (Adenovirus, Lentivirus), siRNA and shRNA knockdown, CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 Knock-out and Knock-in, Domain deletion, Eptopic expression, qPCR, PAGE, Western Blotting, ELISA, Immunohistochemistry, Immunofluorescence, IP(Immunoprecipitation).

Cell Biology: Cell lines culture, Primary cell culture, 3D organoids culture (intestinal stem cell), 3D carcinoma and IBD organoids culture, Cell sorting, Cell functions (isotope labeling, MTT, Edu, TUNEL, Seahorse cell respiration), Aerobic and anaerobic bacterial culture.

Animal Research: Animal Care, handling and breeding, drug delivery (IP, SC, Gavage, IV), Survival blood collection, Intestinal immune cell isolation, mouse models setup (obesity, diabetes, colorectal cancer, inflammatory bowel disease), Gut physiology analysis (nutrient absorption, gut motility, gut permeability, gastric emptying).

Big Data Science: Bulk RNA-seq analysis, ATAC-Seq, ChIP-Seq etc.